There's a great quote from Neil Gaiman going around right now, taken from his speech at the University of Arts n Philadelphia, where he was given an honorary doctorate.
“Remember, whatever discipline you’re in, whether you’re a musician or a photographer, a fine artist or a cartoonist, a writer, a dancer, a singer, a designer — whatever you do, you have one thing that’s unique: You have the ability to make art. And for me, and for so many of the people I’ve known, that’s been a lifesaver, the ultimate lifesaver. It gets you through good times, and it gets you through … the other ones. Sometimes life is hard. Things go wrong — in life and in love and in business and in friendship and in health and in all the other ways life can go wrong. And when things get tough, this is what you should do: Make good art. I’m serious. Husband runs off with a politician? Make good art. Leg crushed and then eaten by mutated boa constrictor? Make good art. IRS on your trail? Make good art. Cat exploded? Make good art. Someone on the Internet thinks what you’re doing is stupid or evil or it’s all been done before? Make good art. Probably things will work out somehow, eventually time will take the sting away, and that doesn’t even matter. Do what only you can do best: Make good art. Make it on the bad days, make it on the good days, too.”
Brilliant. The full speech this is taken from can be viewed at ComicBookResources.